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Harm Reduction

INPUT TABLE   Patients in the experimental group   Patients in the control group   Total number enrolled 2000   Events in the experimental group   Events among controls   Experimental mean follow-up (months)   Control mean follow-up (months)

OUTCOME MEASURE (EVENT) GROUP Yes expected No expected Total Experimental 7 43.50 993 956.50 2000 Control 80 43.50 920 956.50 2000 Total 87 87.00 1913 1,913.00 4000 Hypothesis testing (Chi-squared test)   χ2= 61.253 p =

Best estimate 95% CI   EEO (odd) 0.007   0.003   0.015   CEO (odd) 0.087   0.040   0.189   EER (rate) 0.004   0.002   0.007   CER (rate) 0.040   0.032   0.050   RRR 0.913   0.811   0.959   ARR 0.037   0.028   0.046   NNT (benefit) 27   22   36                 ODDS Ratio 0.081   0.037   0.176   Risk Ratio 0.088   0.041   0.189                 NNT for 1 year 27   22   36   NNT for 2 year 14   11   18